INEDITA-HELIX R&D COLLABORATION
InEdita Bio, a company specializing in genome editing, is thrilled to announce a research and development partnership with Helix Sementes e Biotecnologia.
for sustainable food production
InEdita’s nature-inspired genome-edited crops reduce the use of chemical fertilizers and pesticides in food production. We create varieties resistant to pests and diseases, with enhanced efficiency of water and nutrient acquisition.
Genome-editing
Soybean
Maize
Cotton
Less Pesticides
Less chemical fertilizers
Nutrient acquisition efficiency
Proprietary Platform
Increased Yield
Disruptive Technologies
Nitrogen Fixation
Disease resistance
Insect Resistance
The InEdita Bio genome editing platform enables the development of crops that are more tolerant to pests and diseases, improving yield and benefiting the environment by reducing the use of chemical pesticides.
Genome editing is a revolutionary technology that enables scientists to make precise changes in the genome of almost all organisms.
Millions of tons of pesticides are sprayed to control diseases, with a negative impact on the environment and human health.
We control the expression of regulatory elements, to eliminate the disease-causing agents.
Our platform enables the control of the expression of genes involved in plant growth and development, allowing better performance exploring natural sources of nutrients.
We focus on global crops such as maize and soybean. Our technology improves yield and benefits the environment by reducing the use of chemical fertilizers and pesticides.
Small regulatory sequences down- or up-regulate target genes, making plants resistant to pest and diseases with increased resilience to climate changes.
Our proprietary platform allows the selective use of highly expressed and constitutive genes to deliver regulatory elements to plant cells.
Want to learn more about our technology? Send a message to our team
Brazil is the world largest soybean producer and will become the largest maize producer
InEdita Bio developed a proprietary platform to use highly expressed and constitutive genes to deliver regulatory elements to plant cells.
The tiny regulatory sequences down or up-regulate target genes, making plants resistant to pests and diseases and better adapted to climate changes.
Currently, pests and diseases cause the loss of hundreds of millions of tons of soybean and maize worldwide, despite the spraying of millions of tons of pesticides.
The InEdita Bio technologies will help reduce the environmental and health impact of pesticide spraying by developing plants that are resistant to pest and diseases.
InEdita Bio’s genome editing platform enables the development of pest & disease resistant crops by controlling the expression of regulatory elements.
The highly and constitutive expression of regulatory elements allows the down regulation of pests' and disease´s essential genes.
Towards the future of Plant Biotechnology
Proof of concept of the regulatory element delivery platform that enables the development of any trait in any crop.
Gene discovery for targeting pests and disease essential genes; genome editing strategy designed and implemented.
Routine execution of a highly efficient protocol for soybean transformation. Soybean genome edition pipeline “from seed to seed” implemented.
Laboratory facility constructed in Santo Antonio de Lisboa, Florianópolis.
New disruptive method for tissue-culture free plant transformation allow recovering large number of events in few weeks.
New disruptive platform for targeting multiple essential genes in pests and disease under development
Laboratory and green house phenotyping of genome edited events for soybean Asian rust resistance, maize short stature and maize insect resistance.
R&D partnerships with seed companies for traits/crops of their interest. Use of InEdita Bio technologies to develop traits directedly in their elite inbred lines/varieties to accelerate product development.
Design and start execution of first round of small-scale field trials for best greenhouse-phenotyped events for soybean and maize
Design and start execution of second round of small-scale field trials for best greenhouse phenotyped events for soybean and maize.
After small-scale field trials, we´ll be ready for full-fledged field trials and trait licensing.
Proof of concept of the regulatory element delivery platform that enables the development of any trait in any crop.
Gene discovery for targeting pests and disease essential genes; genome editing strategy designed and implemented.
Routine execution of a highly efficient protocol for soybean transformation. Soybean genome edition pipeline “from seed to seed” implemented.
Laboratory facility constructed in Santo Antonio de Lisboa, Florianópolis.
New disruptive method for tissue-culture free plant transformation allow recovering large number of events in few weeks.
New disruptive platform for targeting multiple essential genes in pests and disease under development
Laboratory and green house phenotyping of genome edited events for soybean Asian rust resistance, maize short stature and maize insect resistance.
R&D partnerships with seed companies for traits/crops of their interest. Use of InEdita Bio technologies to develop traits directedly in their elite inbred lines/varieties to accelerate product development.
Design and start execution of first round of small-scale field trials for best greenhouse-phenotyped events for soybean and maize
Design and start execution of second round of small-scale field trials for best greenhouse phenotyped events for soybean and maize.
After small-scale field trials, we´ll be ready for full-fledged field trials and trait licensing.
Paulo Arruda received his Ph.D. in Genetics from UNICAMP in 1982 and has been a Professor of Genetics at the Department of Genetics State University of Campinas (UNICAMP) and, since then, leading research projects in plant molecular biology and plant genomics. He has published over a hundred scientific papers in high-impact international journals. Professor Arruda is a member of the Brazilian Academy of Sciences, the World Academy of Sciences, the São Paulo State Academy of Science, the National Order of Scientific Merit of the Brazilian Republic Government, and was awarded the Technological Merit Award from the Government of the State of São Paulo. He led the UNICAMP Center for Medicinal Chemistry and the Genomics for Climate Change Research Center. Professor Arruda was co-founder and CSO of the plant biotechnology company Alellyx Applied Genomics, which was acquired by Monsanto in 2008.
Viviane has a Ph.D. in Functional and Molecular Biology-Biochemistry from the University of Campinas (Unicamp). She was a postdoctoral scientist at the Brazilian Biorenewables National Laboratory (CNPEM/LNBR) and the Genomics for Climate Change Research Center at Unicamp. She also worked as a visiting scientist at VIB Flanders Institute for Biotechnology (BE), Max Planck Institute (DE), and the University of Cambridge (UK). Her scientific expertise includes creating, improving, and managing pipelines of crop transformation and genome editing toward improving plant performance under environmental stresses. Viviane is also an expert in molecular engineering, which she uses to develop new and disruptive enabling technologies in plant biotechnology.
José Hernandes holds a Ph.D. in botany from the University of São Paulo (USP). His expertise spans molecular studies on tomato flowering and fruit development at Wageningen University & Research (WUR) in the Netherlands. As a postdoctoral fellow at the Genomics and Transposable Elements Laboratory (GaTE-lab / USP), he delved into understanding the impact of retrotransposons on tobacco homeostasis. José further honed his skills in genome editing as a visiting scientist at the Flanders Institute of Biotechnology (VIB), Belgium. He then assumed the leadership of the genome editing team at the Genomics for Climate Change Research Center (GCCRC / Embrapa / Unicamp), contributing significantly to cutting-edge research on maize transformation and genome editing.
Lucas is an Agronomist Engineer who graduated from Luiz de Queiroz College of Agriculture (ESALQ) with a double degree from the French University AgroParisTech. He also holds a Ph.D. in Biochemistry and Biotechnology from the University of Ghent - Belgium. During his PhD, he studied the regulation of plant immunity by immunoreceptors that recognize small peptides released either by pathogens or by the plant itself. Lucas worked as a postdoctoral researcher at VIB-UGENT Center for Plant Systems Biology, focusing on the molecular breeding of maize. He utilized genome editing techniques, including CRISPR-Cas, in this role to improve complex traits such as plant yield and stature.
Gabriela is a computational biologist with a Ph.D. in bioinformatics from the Universidade Federal de Minas Gerais, MG. Santa Catarina, Florianopolis, SC. Her expertise includes applying computational biology to study molecular mechanisms associated with the immune system and the biology of human diseases. She specialized in developing bioinformatic pipelines using computational tools such as Perl, R, Bash script, SQL, Python languages, artificial intelligence, and machine learning. She uses these tools to answer complex biological questions associated with diseases.
Fernanda has a Ph.D. in Genetics and Molecular Biology from the State University of Londrina, PR. She developed her graduate studies at Embrapa Soybean, one of the Research Institute of the Brazilian Agricultural Research Corporation (Embrapa). Her expertise includes molecular phenotyping of Soybean Asian Rust fungi towards developing resistant soybean varieties. During her graduate studies, she identified and characterized proteins related to fungi virulence and its molecular interaction with the host. She also conducted studies identifying rust resistance genes and functional validation of effector proteins.
Bruna is a Biomedical Scientist with a Ph.D. in Biochemistry from the Federal University of Santa Catarina, SC. Her research expertise focuses on exploring cellular metabolic pathways using advanced molecular biology and histology techniques. With over a decade of experience as a Laboratory Manager, Bruna demonstrates a commitment to research and operational efficiency. Throughout her career, she has played a vital role in assisting teams across various projects, significantly improving the efficiency of research operations.
Tatiane has a Ph.D. in Plant Biotechnology at the Federal University of Lavras, MG (UFLA). During her graduate studies, she optimized a CRISPR/Cas9 system for genome editing of Coffea canephora. She could silence the phytoene desaturase (PDS) marker gene through an optimized coffee transformation method. She was a research fellow at the National Institute of Coffee Science and Technology (INCT-Café), contributing to genome editing projects to obtain low-caffeine coffee plants. Her expertise includes plant tissue culture, genetic transformation, and molecular biology of perennial crops.
Our platform targets specific genes with edited regulatory elements, improving yield and pests and diseases resistance.
Learn more
about InEdita Bio
Learn more
about InEdita Bio
Gene editing technology refers to the set of techniques that allows scientists to precisely modify the DNA of an organism. One of the most revolutionary tools in this field is CRISPR-Cas9, which stands for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9. This technology enables scientists to target specific genes within an organism's DNA and either introduce modifications, insert new genetic material, or deactivate certain genes.
The CRISPR-Cas9 system works by utilizing a guide RNA molecule to target a specific sequence in the DNA, and the Cas9 protein acts as a molecular pair of "scissors," cutting the DNA at the desired location. Once the DNA is cut, the cell's natural repair machinery can be harnessed to introduce changes to the genetic code.
Gene editing has transformative potential for various applications, including agriculture, medicine, and biotechnology. It allows for the development of genetically modified crops with enhanced nutritional content, the correction of genetic defects in humans, and the potential treatment of various diseases. However, ethical concerns surround the technology, particularly regarding unintended consequences and the possibility of "designer babies." As research progresses, gene editing continues to be a dynamic and evolving field with both promise and challenges.
Regulatory elements in plant genomes are DNA sequences that control the expression of genes, playing a crucial role in the regulation of various biological processes. These elements include promoters, enhancers, and transcription factor binding sites. Promoters are regions where RNA polymerase and other transcriptional machinery bind to initiate gene transcription. Enhancers are distant regulatory elements that can enhance gene expression by interacting with promoters. Transcription factor binding sites are specific DNA sequences where regulatory proteins, such as transcription factors, attach to modulate gene expression.
These regulatory elements orchestrate the precise timing, location, and level of gene expression, influencing plant growth, development, and responses to environmental stimuli. Understanding and manipulating these elements have significant implications in agriculture, enabling the development of genetically modified crops with improved traits, such as increased yield, resistance to pests, and tolerance to environmental stressors. However, the use of these elements in genetic engineering is subject to strict regulatory oversight to ensure safety and ethical considerations.
The safety of editing plant genes depends on several factors, including the specific techniques used, the nature of the modifications, and thorough regulatory assessments. Generally, gene editing in plants has shown promise in creating crops with improved traits like resistance to diseases, enhanced nutritional content, and increased yield. Techniques like CRISPR-Cas9 offer precision, minimizing unintended effects. However, potential ecological and environmental impacts, as well as unintentional off-target mutations, need thorough evaluation. Regulatory frameworks vary globally, with some countries imposing strict guidelines for genetically modified organisms. Rigorous testing, transparent risk assessments, and adherence to ethical guidelines are crucial to ensuring the safety of edited plant genes, addressing concerns about unintended consequences and long-term environmental effects. Responsible and well-regulated gene editing practices can contribute positively to agriculture and food security.
"Asian soybean rust" is a fungal disease caused by Phakopsora pachyrhizi. This pathogen can severely affect soybean crops, leading to decreased yields and economic losses. Asian soybean rust spreads rapidly in warm and humid conditions, making it a significant concern for soybean farmers, particularly in Asia and other regions with suitable climates for the disease. Early detection, fungicide application, and resistant crop varieties are key strategies to manage the impact of Asian soybean rust on agricultural productivity.
Maize, also known as corn, is one of the world’s most widely cultivated crops, with a global presence and significant economic importance. Originating in the Americas, maize has become a staple food and a versatile commodity. It serves as a primary food source for millions, as well as a critical component in livestock feed and industrial products. Major maize-producing countries include the United States, China, Brazil, Argentina, and India. The crop adapts well to diverse climates and is grown on every continent except Antarctica. Maize varieties range from traditional open-pollinated types to modern hybrids developed through advanced breeding techniques. Its uses extend beyond human consumption to include biofuel production, industrial applications, and animal feed. The crop’s significance in global agriculture underscores its role in addressing food security, economic development, and various industries worldwide.
Genetics plays a pivotal role in advancing maize crops through selective breeding and biotechnology. Traditional breeding methods involve selecting plants with desired traits, such as high yield, resistance to diseases, and adaptability to environmental conditions. Modern molecular genetic techniques, including marker-assisted breeding and genetic modification, have accelerated the development of improved maize varieties. Marker-assisted breeding helps identify and select plants with specific genes linked to desired traits more efficiently. Genetic modification, using tools like CRISPR-Cas9, allows for precise gene editing to enhance traits like pest resistance, drought tolerance, and nutritional content. These genetic approaches contribute to the development of maize varieties that can address global challenges such as climate change, pests, and food security, ensuring a more resilient and productive crop for the future. However, the use of genetic technologies in crops is subject to regulatory scrutiny and considerations of environmental and ethical implications.
Over the past 20 years, maize crop yields have seen significant advancements, driven by technological innovations and improved agricultural practices. The global average maize yield has steadily increased, owing to the adoption of hybrid varieties, precision farming techniques, and advancements in crop management. Key contributors include the widespread use of genetically modified maize varieties, such as those engineered for pest resistance and herbicide tolerance. The adoption of improved agronomic practices, including precision agriculture, optimized irrigation, and enhanced fertilization, has also played a crucial role. However, yield variations exist due to factors like climate conditions, pest outbreaks, and regional disparities in technology adoption. Continuous research and development in maize genetics and agronomy aim to sustain and further increase yields, addressing the growing demand for maize as a staple food, animal feed, and industrial raw material on a global scale.
Soybean crops hold immense relevance in today’s world due to their multifaceted uses and economic impact. As a crucial source of protein and oil, soybeans are a staple in human and animal diets, contributing significantly to global food security. The versatile crop is a key ingredient in a wide range of food products, from cooking oils and tofu to protein-rich animal feeds. Additionally, soybeans play a vital role in sustainable agriculture, acting as a nitrogen-fixing legume that enriches soil fertility. Furthermore, soybeans are a primary raw material for various industrial products, including biodiesel, plastics, and pharmaceuticals. The economic importance of soybeans is underscored by major global producers such as the United States, Brazil, and Argentina. The crop’s resilience, adaptability, and diverse applications make soybeans a cornerstone in addressing nutritional, environmental, and economic challenges worldwide.
Genetics is instrumental in enhancing soybean crops through both traditional breeding methods and advanced biotechnology. Traditional breeding focuses on selecting soybean plants with desirable traits such as high yield, disease resistance, and improved nutritional content. Molecular genetics and marker-assisted breeding expedite this process by identifying and selecting plants with specific genes linked to these traits. Additionally, genetic modification techniques, like CRISPR-Cas9, allow for precise editing of the soybean genome to enhance traits such as herbicide resistance, pest tolerance, and nutritional quality. These genetic advancements aim to create soybean varieties that are more resilient, productive, and adaptable to changing environmental conditions, contributing to global food security and sustainable agriculture. However, like with other genetically modified crops, the use of genetic technologies in soybeans is subject to regulatory oversight and considerations of environmental and ethical implications.
Yes, soybean yields have shown improvement over the years, driven by advancements in genetics, agronomic practices, and technology adoption. In the United States, for example, soybean yields have steadily increased. According to the United States Department of Agriculture (USDA), the average soybean yield per acre in the U.S. has risen from around 33 bushels in the early 1980s to over 50 bushels in recent years. This upward trend is attributed to the widespread adoption of genetically modified soybean varieties, precision farming techniques, and improved pest and disease management. Similarly, other major soybean-producing countries, such as Brazil and Argentina, have experienced yield increases due to the adoption of improved varieties and agricultural practices. These advancements in soybean yields contribute to meeting the growing global demand for soybeans in various industries, including food, animal feed, and biofuels.
InEdita Bio, a company specializing in genome editing, is thrilled to announce a research and development partnership with Helix Sementes e Biotecnologia.
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